相关实验视频
Updated: May 22, 2025

08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
11.1K
在早期月经期和多囊性卵巢综合征中共享的病理生理机制和遗传因素
Flavia Rezende Tinano1, Iza Franklin Roza Machado1, Ana Claudia Latronico1
1Discipline of Endocrinology & Metabolism, Department of Internal Medicine, University of Sao Paulo Medical School, University of Sao Paulo, Sao Paulo, Sao Paulo 01246 903, Brazil.
概括
初潮的早期年龄 (AAM) 和多囊卵巢综合征 (PCOS) 具有共同的遗传和神经内分泌路径. 了解这些联系可能会揭示生殖和代谢障碍的新治疗点.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 神经内分泌学神经内分泌学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 初潮的早期年龄 (AAM) 和多囊卵巢综合征 (PCOS) 是不同的,但重叠的生殖和代谢障碍.
- 这两种情况都涉及神经内分泌通路的失调,这些通路控制着淋巴激素的分泌,特别是黄素化激素.
- 共享的病理生理学包括正能量平衡和异常的代谢状态.
研究的目的:
- 探索中部早期青春期/早期AAM和PCOS之间共享的病理生理机制.
- 检查这些神经内分泌生殖条件之间的遗传和表观遗传因素.
- 为未来的研究和治疗策略提供见解.
主要方法:
- 对流行病学研究和遗传关联研究的审查.
- 对全基因组关联研究 (GWAS) 和高通量测序数据的分析.
- 探索FSHB,FTO和DLK1.1等基因中的遗传变异.
主要成果:
- 与AAM和PCOS相关的常见遗传变异在调节神经内分泌轴和肥胖的基因中被发现.
- 在DLK1中罕见的功能丧失变异与CPP,早期AAM,PCOS和不良代谢结果有关.
- 有共同的神经内分泌和代谢失调的证据.
结论:
- 早期的AAM和PCOS具有重要的病理生理和遗传联系.
- 遗传因素,包括FSHB,FTO和DLK1的变异,在这两种疾病中都起作用.
- 对这些联系的进一步研究可以为改善患者结果的新型治疗干预提供信息.
相关概念视频
Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Hormonal Regulation of the Menstrual Cycle
249
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
249
Disorders of the Female Reproductive System
286
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
286
Hormonal Control of the Ovarian Cycle
371
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
371
Ovarian Cycle
889
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
889
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
342
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
342

