评估前期治疗在预防对非离子对比剂过敏反应的有效性
Shinya Suzuki1, Shungo Imai2, Akinori Omata3
1Center for Experiential Pharmacy Practice, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Biological & pharmaceutical bulletin
|March 12, 2025
概括
类固醇前期治疗不能有效地预防非离子对比剂的急性过敏反应. 这项研究发现,预先治疗和未预先治疗患者之间的反应率没有显著差异.
科学领域:
- 放射学 放射学是一门学科.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 基于的对比剂可以引起急性过敏反应.
- 在日本,类固醇前期治疗是一种常见的预防措施.
- 对其在预防对比剂过敏的有效性的证据是有限的.
研究的目的:
- 评估类固醇前期治疗在预防急性过敏反应方面的有效性.
- 分析非离子对比剂诱导的反应.
- 使用倾向性得分匹配来比较结果.
主要方法:
- 对接受非离子对比剂的患者进行了回顾性研究.
- 包括没有先前过敏反应的首次患者.
- 倾向性得分匹配用于比较预药和非预药组.
主要成果:
- 422名患者 (每组211名) 与19976名初始患者进行了匹配.
- 过敏反应发生在3.32% (预制药) 和0.95% (非预制药) 的患者中.
- 在前期治疗组中反应的几率比为3.500 (95% CI,0.727-16.848),没有显著差异.
结论:
- 类固醇前期治疗没有证明在预防对非离子对比剂的急性过敏反应方面有效.
- 没有达成对前期治疗的建议,特别是对于过敏患者.
- 可能需要进一步的研究来澄清最佳的预防策略.
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