心血管生物学年龄与心血管疾病之间的关联 - 一项前性队列研究
Jiajie Cai1, Rui Yu1, Ning Zhang1
1West China School of Public Health and West China Fourth Hospital, Sichuan University.
概括
心血管生物学年龄 (CBA) 与心血管疾病 (CVD) 风险增加有关. 这项研究揭示了CBA作为各种心血管疾病类型的早期指标,为预防策略提供了洞察力.
科学领域:
- 生物医学科学 生物医学科学
- 心血管研究研究心血管研究
- 老年学是指老年学的学科.
背景情况:
- 生物年龄是与年龄相关的疾病和心血管疾病的风险因素.
- 心血管生物学年龄 (CBA) 和各种心血管疾病 (CVD) 之间的具体关系需要进一步澄清.
研究的目的:
- 调查CBA与17种不同类型的心血管疾病之间的关联.
- 探索CBA,CBA加速和心血管疾病发病率之间的潜在非线性关系.
主要方法:
- 从262,343名英国生物库参与者的复合生物标志物中使用克莱梅拉-杜巴尔方法 (KDM-CBA) 构建了CBA.
- 计算KDM-CBA加速为KDM-CBA和时间年龄之间的差异.
- 采用了Cox的比例危险模型和受限制的立方螺纹模型来分析关联.
主要成果:
- 增加的KDM-CBA与各种心血管疾病类型显著相关,包括高血压 (HR=2.115) 和冠状动脉样硬化 (HR=1.711).
- KDM-CBA加速表明与心血管疾病发病率有类似的关联.
- 无论是KDM-CBA还是它的加速都表现出J型非线性关联与几乎所有分析的CVD类型.
结论:
- 可证明,CBA与较高的心血管疾病发病率有关.
- 这一发现支持衰老作为各种心血管疾病的共同途径,并突出了CBA作为早期心血管疾病风险指标的潜力.
- 结果为开发有针对性的心血管疾病干预提供了有价值的见解.
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