在精神分裂症中出现大脑不对称
Francesca Martini1, Marco Spangaro1, Jacopo Sapienza2
1Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Handbook of clinical neurology
|March 12, 2025
概括
减少大脑不对称性是精神分裂症的一个关键特征,可能会影响语言和认知. 这种"旧概念"提供了对精神分裂症的持续洞察.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 早期的观察发现,精神分裂症患者的右手使用率较低.
- 这导致了将大脑不对称与精神分裂症发展联系在一起的假设.
- 减少大脑不对称现已成为各种神经成像研究中一致报告的特征.
研究的目的:
- 探索大脑不对称性在精神分裂症中的作用.
- 调查减少不对称性和认知/精神病理维度之间的相关性.
- 重新评估精神分裂症发病过程中不对称性丧失的重要性.
主要方法:
- 通过脑电图 (EEG),脑磁图 (MEG),磁共振成像 (MRI) 和功能性MRI (fMRI) 的发现进行审查.
- 分析与语言相关的大脑区域的结构不对称性.
- 在进化和精神病理框架内重新处理数据.
主要成果:
- 在多种技术中,在精神分裂症中减少/失去大脑不对称性的一致报告.
- 在减少不对称性和认知/精神病理缺陷之间发现了显著的相关性.
- 在语言区域如Sylvian裂和时间平面中观察到的结构不对称性的缺失或逆转.
结论:
- 失去大脑不对称性和相关的语言障碍可能是精神分裂症的主要因素.
- 尽管病因复杂,但大脑不对称仍然是精神分裂症研究的重要领域.
- 大脑不对称的概念为精神分裂症的临床医生和研究人员提供了宝贵的见解.
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