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吸烟与心血管损害的亚临床标记物之间的关联
Zhiqi Yao1, Erfan Tasdighi1, Zeina A Dardari1
1Ciccarone Center for Prevention of Cardiovascular Disease, Johns Hopkins Medicine, Baltimore, Maryland, USA.
吸烟显著提高了心血管损害标志物,包括炎症和动脉样硬化. 戒烟会随着时间的推移而降低这些风险,尽管有些影响会长期存在.
科学领域:
- 心血管疾病的研究研究.
- 烟草控制和公共卫生问题
- 在吸烟相关疾病中的生物标志物分析.
背景情况:
- 烟草吸烟是心血管损伤的既定危险因素.
- 了解吸烟强度,戒烟持续时间和心血管标志物之间的剂量反应关系对于公共卫生干预至关重要.
研究的目的:
- 调查吸烟强度,包装年和戒烟后的时间与炎症,血栓形成和亚临床动脉样硬化标志物之间的详细关联.
- 量化各种吸烟参数和心血管损害指标的剂量反应关系.
主要方法:
- 分析了22个队列中的182,364名参与者 (跨队列协作).
- 评估自我报告的吸烟状态,强度和包装年,同时测量炎症,血栓形成和亚临床动脉样硬化标志物.
- 利用多变量回归模型和受限立方线来评估关联.
主要成果:
- 与从未吸烟者相比,目前和前吸烟者表现出所有亚临床心血管标志物的较高水平.
- 吸烟强度与大多数标志物有明确的剂量反应关系,即使在每天吸20支烟后,效果也会持续下去.
- 停止导致标志物水平大幅降低,大多数在30年后恢复到基线,除了冠状动脉.
结论:
- 吸烟参数与亚临床心血管损害标志物具有强烈的剂量反应关系.
- 这些标记物对吸烟暴露的敏感性突显了它们在监管烟草制品方面的潜在实用性.
- 长期戒烟与心血管风险降低有关,强调戒烟的好处.
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