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急性辐射综合征的细胞因子治疗

Hillard M Lazarus¹, Robert Peter Gale²

¹Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

Best practice & research. Clinical haematology

|March 12, 2025

概括

放射性事故可能导致骨髓衰竭,称为血液形成性急性辐射综合征 (H-ARS). 像菲尔格拉斯蒂姆和萨格拉斯蒂姆这样的重组生长因子为H-ARS治疗提供了有利的风险-收益概况.

科学领域:

医学科学医学科学医学科学
辐射瘤学辐射瘤学
血液学血液学血液学

背景情况:

放射性事故经常发生,导致大量的辐射暴露和死亡事故.
急性高剂量电离辐射暴露可能导致骨髓衰竭,称为血液形成急性辐射综合征 (H-ARS).

研究的目的:

评估复合人体颗粒细胞 - 菌群刺激因子 (rhu G-CSF;filgrastim) 和复合人体颗粒细胞 - 巨细胞 - 菌群刺激因子 (rhu GM-CSF;sargramostim) 在管理H-ARS中的作用.
为了比较这些生长因子的益处与风险比率与H-ARS的传统造血细胞移植.

主要方法:

文献综述和对有关H-ARS治疗方式的现有数据的分析.
评估与辐射暴露有关的临床前和临床环境中rhu G-CSF和rhu GM-CSF的疗效和安全概况.

主要成果:

造血干细胞和祖细胞损伤是急性高剂量辐射暴露的主要后果.
再组合生长因子显示,与血液细胞移植相比,H-ARS的益处与风险比较有利.

结论:

建议在暴露于急性高剂量电离辐射的患者中,早期使用rhu G-CSF (filgrastim) 和rhu GM-CSF (sargramostim).
这些重组生长因子代表了缓解H-ARS的有希望的治疗策略,与骨髓移植相比,具有优势.

关键词:

急性辐射综合征是什么殖民地刺激因子菲尔格拉斯蒂姆的使用在G-CSF中使用.转基因-CSFF是什么意思骨髓状细胞的生长因子辐射和核反制措施.再组合的人类颗粒细胞殖民地刺激因子 (rhu G-CSF)再组合的人类颗粒细胞-巨细胞殖民地刺激因子 (rhu GM-CSF)萨格拉姆给了我一个激励.

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