细胞因子在血液细胞移植和相关的细胞疗法中的细胞因子
Abdul-Hamid Bazarbachi1, Markus Y Mapara2
1Division of Hematology/Oncology, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, NY, USA.
Best practice & research. Clinical haematology
|March 12, 2025
概括
细胞因子是干细胞移植和免疫疗法的关键,影响了效益和副作用,如移植与宿主疾病 (GVHD). 新的治疗方法旨在利用它们的力量,同时控制毒性.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 细胞因子是免疫系统中至关重要的信号分子,影响血液形成,免疫反应和炎症.
- 它们的作用在造血细胞移植 (HCT) 和免疫效应细胞 (IEC) 疗法中尤为重要,在这些疗法中它们调解了有益和有害的效应.
- 细胞因子有助于严重的并发症,如移植对宿主疾病 (GVHD),细胞因子释放综合征 (CRS) 和免疫效应细胞相关的神经毒性综合征 (ICANS).
研究的目的:
- 审查细胞因子在HCT和IEC治疗中的多方面的功能.
- 检查细胞因子对造血细胞移植和移植后免疫恢复的影响.
- 探索减轻细胞因子中介毒性和提高治疗结果的策略.
主要方法:
- 文献综述,重点关注HCT和IEC疗法中的细胞因子功能.
- 分析当前和新兴的细胞因子的治疗应用.
- 对管理细胞因子相关不良事件的策略的评估.
主要成果:
- 细胞因子极大地影响了移植,免疫复原以及GVHD,CRS和ICANS的发展.
- 细胞因子抑制剂 (例如,托西利祖马布,阿纳金拉) 和JAK抑制剂 (例如,鲁克索利提尼布) 是控制细胞因子中介毒性的关键.
- 像CSF1R封锁这样的新方法显示出治疗耐火性慢性GVHD的前景.
结论:
- 了解细胞因子生物学对于优化HCT和IEC疗法至关重要.
- 有针对性的细胞因子抑制和新的治疗策略正在改善患者的治疗结果,并管理与治疗相关的毒性.
- 对细胞因子调节的进一步研究具有促进移植和免疫治疗的巨大潜力.
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