口服SARS-CoV-2感染和长期Covid的风险
Joel Schwartz1, Kristelle Capistrano2, Heba Hussein3
1Department of Oral Medicine and Diagnostic Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
Reviews in medical virology
|March 12, 2025
概括
SARS-CoV-2 感染会破坏口腔微生物组,恶化口腔健康,增加病毒入侵和PASC的易感性. 糟糕的口腔健康促进病毒热带和全身炎症,影响整体健康.
科学领域:
- 口腔微生物学 口腔微生物学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- SARS-CoV-2 感染口腔上皮细胞,导致口腔病理和COVID-19 (PASC) 后急性后续.
- 以前存在的口腔疾病和SARS-CoV-2感染诱导的异位生物分裂症加剧了口腔健康和粘膜完整性的不良状况.
研究的目的:
- 阐明口腔微生物组在SARS-CoV-2感染和发病过程中的作用.
- 了解口腔失生症如何影响病毒的进入,免疫反应和PASC的发展.
主要方法:
- 审查有关SARS-CoV-2,口腔微生物组和PASC的现有文献.
- 分析分子机制,包括病毒进入途径和宿主微生物相互作用.
主要成果:
- 口腔失调促进了SARS-CoV-2通过ACE2和TMPRSS2进入,并改变了代谢途径.
- 微生物代谢物和蛋白质模仿物促进病毒的附着和进入,同时损害口腔粘膜免疫力.
- 神经蛋白介导的膜重组有助于病毒的进入和PASC的发病,扩展到全身组织.
结论:
- 被破坏的口腔微生物组促进SARS-CoV-2的热流,削弱抗病毒防御,增加感染易感性.
- 口腔健康功能障碍加剧病毒感染,并导致全身炎症,在口腔和非口腔组织之间产生双向效应.
- 这些发现强调了口腔健康和全身PASC发育之间的关键联系.
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