饮食习惯和糖尿病病风险:一个双样本和多变量门德尔随机化研究
Ziqi Zhang1, Jieyu Niu2, Wenhao Sun3
1Department of Endocrinology, Nanjing Hospital of Chinese Medicine, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Renal failure
|March 13, 2025
概括
避免摄入糖可能会因果性地增加患糖尿病病 (DKD) 的风险. 相反,在这项研究中,食用全谷物并没有对饮食习惯和DKD风险产生保护作用.
科学领域:
- 遗传学和流行病学
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症.
- 人们怀疑饮食习惯会影响DKD风险,但因果关系尚不清楚.
- 门德尔随机化 (MR) 为研究这种因果关系提供了一个强大的工具.
研究的目的:
- 调查各种饮食习惯与发展DKD的风险之间的因果关系.
- 为了确定可能增加或减少DKD风险的特定饮食因素.
主要方法:
- 使用了双样本和多变量门德尔随机化 (MR) 分析.
- 采用来自欧洲人口的全基因组关联研究 (GWAS) 数据,包括83种饮食习惯和糖尿病病的数据.
- 经过验证的发现和执行的多变量MRI,包括食后葡萄糖数据.
主要成果:
- 确定了戒糖与增加DKD风险之间的因果关系 (OR 2.86).
- 发现全谷物/多谷物面包消费对DKD (OR 0.53) 有潜在的保护作用.
- 多变量MR表明,从不吃糖会显著增加DKD风险 (OR0.08),而全谷物消费没有显著影响.
结论:
- 从来没有吃过糖是因果关系增加患DKD的风险.
- 糖尿病患者应在合理范围内控制糖的摄入量.
- 全谷物消费对DKD的保护作用需要进一步研究.
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