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泰格-BMI与早期高血压之间的关联:来自NHANESES的证据
Wushuang Li1, Chenliang Ge2, Jianyong Zhou3
1Department of Critical Care Medicine, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, No. 85 Hedi Road, Nanning, 530021, Guangxi, China.
Scientific reports
|March 13, 2025
概括
三糖糖-体质指数 (TyG-BMI) 与40岁以下成年人早期高血压 (EHT) 有着强烈的联系. 较高的TyG-BMI水平显著增加了患EHT的风险,突出了其作为早期检测工具的潜力.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征研究 代谢综合征研究
- 公共卫生 公共卫生
背景情况:
- 早期高血压 (EHT) 具有显著的长期心血管风险.
- 识别可靠的ETH风险标志物对于及时干预至关重要.
研究的目的:
- 在40岁以下的美国成年人群中调查甘油三糖-体重指数 (TyG-BMI) 和EHT之间的关联.
- 探索氧化应激和炎症在这种关系中的潜在调解作用.
主要方法:
- 分析了来自2009-2018年国家健康和营养检查调查 (NHANES) 的5193名40岁以下成年人的数据.
- 使用加权后勤回归模型来评估TyG-BMI和EHT之间的关联,并对混因素进行调整.
- 进行中介分析以确定潜在的中介物,如氧化应激和炎症标志物.
主要成果:
- 与对照组相比,患有EHT的参与者表现出明显更高的TyG-BMI (P < 0.001).
- 泰格-BMI的最高四分位数独立地与EHT的6.47倍增加的几率相关 (OR:6.47,95%CI:4.35-9.61) 与最低四分位数相比.
- -氨基转移酶 (GGT) 和尿酸成为显著的潜在媒介.
结论:
- 较高的TyG-BMI与早期高血压的风险增加有显著关联.
- TyG-BMI可以作为一种实用的临床工具,用于早期识别和管理面临ETH风险的个体.
- 通过TyG-BMI进行早期检测可以促进干预措施,以减轻未来的心血管风险.
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