腹腔大动脉瘤是小鼠和人类的一种全身和普遍的动脉巨变
Zhaohua Cai1, Liang Fang1, Zhanying Wei2
1Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Scientific reports
|March 13, 2025
概括
腹腔大动脉瘤 (AAA) 是一种系统性动脉扩张,影响整个大动脉及其分支,与胸腔动脉瘤不同. 这种普遍扩大在人类患者和新型小鼠模型中都被观察到,表明系统性疾病过程.
科学领域:
- 血管生物学 血管生物学
- 心血管研究研究心血管研究
- 医疗成像医学成像
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 的根本原因尚未完全理解.
- 越来越多的证据表明AAA可能是一种全身血管疾病.
- 将AAA与上升胸前动脉动脉瘤 (ATAA) 区分开来,对于了解疾病机制至关重要.
研究的目的:
- 通过比较患者和小鼠模型中的整个大动脉及其分支来研究腹腔大动脉动脉瘤 (AAA) 的全身性质.
- 描述AAA,上升胸前大动脉动脉瘤 (ATAA) 和健康对照之间的形态差异.
- 建立和分析AAA研究的新型小鼠模型.
主要方法:
- 计算机断层扫描血管造影 (CTA) 用于评估47名AAA患者,47名ATAA患者和46名对照者的大动脉形态学.
- 开发了一种受托莫西芬诱导的Lkb1flox/flox;Myh11-Cre/ERT2小鼠模型来研究AAA进展.
- 用CTA,MRI和组织病理学来评估小鼠模型中的大动脉尺寸和形态.
主要成果:
- AAA患者表现出整个大动脉及其主要分支的扩散扩大.
- 上升胸前大动脉动脉瘤 (ATAA) 患者显示局部扩张局限于上升大动脉.
- Lkb1flox/flox;Myh11-Cre/ERT2小鼠自发发展了AAA和相关的外周动脉动脉瘤,与野生型小鼠相比,大动脉扩大普遍.
结论:
- 腹腔大动脉动脉瘤 (AAA) 代表了影响整个大动脉及其分支的系统性动脉扩张.
- 上升胸前动脉动脉瘤 (ATAA) 是一种局部疾病.
- 在人类患者和小鼠模型中发现的结果支持AAA的系统性.
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