在ALS中FTD频谱内外的认知障碍:开发一种补充认知屏幕
Annebelle Michielsen1, Kevin van Veenhuijzen1, Fenna Hiemstra1
1Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, G03.232, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
Journal of neurology
|March 13, 2025
概括
补充认知ALS屏幕 (C-CAS) 识别了前性痴呆症 (FTD) 范围内的和超越的肌缩侧面硬化症 (ALS) 的认知障碍. 这个新工具补充了现有的选,帮助个性化的ALS患者护理和研究.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 认知障碍在ALS中很常见,影响前性痴呆 (FTD) 谱内的和超越的区域.
- 现有的查工具可能无法完全捕捉ALS的认知缺陷范围.
研究的目的:
- 为了调查肌缩侧面硬化症 (ALS) 的认知障碍.
- 扩大认知评估的范围,超出前性痴呆症 (FTD) 的既定范围.
- 评估补充认知ALS屏幕 (C-CAS) 在ALS中的实用性.
主要方法:
- 补充性认知ALS屏幕 (C-CAS) 是为了评估爱丁堡认知和行为ALS屏幕 (ECAS) 不涵盖的认知领域而开发的.
- 收集了规范性数据,并根据年龄,性别和教育程度调整了模型.
- 对照组的分数低于第5百分位被认为是异常的;在184名ALS患者和314名对照组中比较了C-CAS损伤.
主要成果:
- C-CAS是一种可行且耐受良好的15-20分钟评估.
- 在所有C-CAS项目中,ALS患者表现出损伤.
- 在12-16%的患者中,C-CAS确定了FTD频谱 (社会认知,抑制,灵活性) 和超越 (视觉构造,非语言记忆,身体定向) 的损伤,与ECAS的重叠很小.
- 24%的ALS患者有异常的C-CAS总分,C-CAS检测到额外的损伤15%,与ECAS相比.
结论:
- 在ALS的认知障碍存在于FTD频谱内外,经常被当前查工具遗漏.
- C-CAS有效地补充了ECAS,增强了ALS的认知评估.
- 这种改进的评估促进了个性化的患者咨询和更精确的研究分层在ALS.
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