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在COVID-19中使用VEGF-A:对其预后价值进行系统审查和元分析方法

Seyed Sobhan Bahreiny¹, Mohammad-Navid Bastani^2,3, Hossein Keyvani⁴

¹Physiology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Clinical and experimental medicine

|March 13, 2025

概括

血管内皮生长因子A (VEGF-A) 水平升高表明COVID-19患者的预后更差. 这一元分析证实了VEGF-A的存在.

科学领域:

生物医学科学生物医学科学
免疫学免疫学免疫学
病理生理学病理生理学

背景情况:

血管内皮生长因子A (VEGF-A) 在COVID-19病理生理学中发挥着关键作用.
确定COVID-19患者VEGF-A水平的预后值对于疾病管理至关重要.

研究的目的:

系统地审查和元分析COVID-19患者VEGF-A水平升高的预后价值.
评估VEGF-A水平与COVID-19疾病严重程度之间的关联.

主要方法:

在主要的电子数据库中进行系统的文献搜索,截至2024年1月.
11项研究的元分析,包括1119名COVID-19患者,使用随机效应模型计算标准化平均差异 (SMD).
进行元回归和子组分析,以探索异质性来源,包括年龄组,测试技术和身体质量指数 (BMI).

主要成果:

升高的VEGF-A水平与COVID-19疾病严重程度的增加显著相关 (汇总的SMD=0.525,P=0.028).
在VEGF-A水平和测定技术和BMI之间发现了潜在的相关性.
在不同年龄组中注意到VEGF-A和COVID-19关系的变化.

结论:

在COVID-19患者中,VEGF-A具有显著的预后价值.
了解VEGF-A和COVID-19的相互作用可以为向治疗和预后指标提供信息.

关键词:

根据COVI-19的情况,内皮功能障碍SARS-CoV-2病毒在VEGF-A的基础上.血管内皮生长因子血管内皮生长因子

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