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在老年小鼠中,TREM2通过抑制NLRP3/caspase-1通路和通过PLCγ2激活细胞亡来调节术后认知功能

Xinyue Zhang¹, Renyi Wang¹, Xue Pan¹

¹Department of Anesthesiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Molecular neurobiology

|March 13, 2025

概括

准TREM2-PLCγ2通路可以预防手术后认知功能障碍 (POCD). 激活TREM2可以减少神经炎症和神经细胞亡,改善手术后的认知功能.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

手术后认知功能障碍 (POCD) 在老年患者中很常见.
神经炎症是导致POCD的一个关键因素.
在POCD中TREM2-PLCγ2信号通路的作用尚未完全理解.

研究的目的:

研究TREM2-PLCγ2途径在缓解神经炎症,神经元亡和手术后认知障碍方面的治疗潜力.
阐明TREM2,PLCγ2和NLRP3炎症体之间的机制关系.

主要方法:

在体内 (小鼠手术模型) 和体内 (微质细胞) 的研究.
用TREM2激活COG1410的使用.
TREM2和PLCγ2的淘汰实验,SYK抑制和RNA测序.

主要成果:

手术增加了NLRP3炎症酶激活,炎症和亡.
COG1410治疗减少了这些标记物,并改善了认知功能.
TREM2激活促进了SYK依赖的PLCγ2酸化,抑制了NLRP3炎症酶.

结论:

TREM2通过SYK酸化调节PLCγ2活性,减少神经炎症和亡.
准TREM2-PLCγ2通路是预防和治疗POCD的一个有希望的策略.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.微质细胞中的微质细胞神经炎症是一种神经炎症.在PLCγ2中.手术后的认知功能障碍在TREM2中,我们可以使用TREM2.

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