孕期体重轨迹和早期后代的生长因孕期糖尿病而异:基于人口的队列研究
Ye Huang1,2, Diliyaer Ainiwan1,2, Yiwen Qiu1,2
1Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
孕期体重增加 (GWG) 轨迹会影响儿童的早期生长. 这种关联根据妊娠糖尿病 (GDM) 状态而异,影响非GDM怀孕中的后代长度,并在GDM怀孕中增加体重和肥胖风险.
科学领域:
- 孕产妇和胎儿的医学
- 儿科生长和发育的发展.
- 公共卫生营养 公共卫生营养
背景情况:
- 孕期体重增加 (GWG) 是影响胎儿发育和早期儿童成长的关键因素.
- 了解GWG的轨迹,而不仅仅是总量,可能会为后代的结果提供更细致的见解.
- 孕期糖尿病 (GDM) 是一种常见的并发症,可能会改变GWG和儿童生长之间的关系.
研究的目的:
- 调查不同妊娠体重增加 (GWG) 轨迹与儿童早期生长参数至36个月龄之间的关联.
- 探索这种关联是否因妊娠糖尿病 (GDM) 的存在或不存在而改变.
主要方法:
- 隐性类轨迹分析被用来从母体体重数据中建模不同的GWG模式.
- 应用了通用估计方程来分析确定GWG轨迹与36个月前后代的人类测量结果 (长度,体重,BMI z-scores) 之间的关联.
- 数据从中国周山市13,424名参与者的电子医疗记录中提取,包括GDM和非GDM组.
主要成果:
- 确定了三种不同的GWG轨迹:中度,缓慢-快速和快速-缓慢.
- 在整体队列和非GDM组中,缓慢-快速GWG模式与较低的后代长度z分数相关,而快速-缓慢模式与较高的长度z分数相关.
- 在GDM组中,快速-缓慢的GWG模式与更高的后代体重和BMIz-score显著相关,以及超重/肥胖风险增加 (OR=1.40).
结论:
- 孕期体重增加轨迹显著影响儿童早期的成长,影响因GDM状态而异.
- 在没有GDM的怀孕中,GWG轨迹主要影响后代的长度.
- 在患有GDM的怀孕中,早期的快速体重增加模式与后代体重,BMI和超重/肥胖风险的增加有关.
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