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在血清素蝙蝠中,皮下巨细胞瘤与结节转移

Gauthier Terrade^1,2, Valentine Muller¹, Gaël Berthévas³

¹Ecole nationale vétérinaire d'Alfort, Unité d'Histologie et d'Anatomie Pathologique, Maisons-Alfort, France.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

|March 13, 2025

概括

一个血清素蝙蝠 (Eptesicus serotinus) 的皮下瘤被诊断为恶性瘤 (MCT). 这是首个在蝙蝠中报告的病例,强调了需要进一步研究KIT免疫组织化学来诊断的需要.

科学领域:

兽医病理学兽医病理学
野生动物瘤学野生动物瘤学
比较瘤学的比较.

背景情况:

巨细胞瘤 (MCTs) 在家禽中很常见,但在野生动物中很少报告.
脊椎动物物种中瘤的发生和行为仍未得到充分研究.

研究的目的:

为了记录一种血清素蝙蝠 (Eptesicus serotinus) 中皮下巨细胞瘤的第一个病例.
描述瘤的组织学和免疫组织化学特征.
评估鸟MCT中恶性瘤和转移的可能性.

主要方法:

来自野生血清素蝙蝠的皮下部瘤的组织学检查.
吉姆萨染色用于识别细胞形态和细胞内质粒.
免疫组织化学 (IHC) 用于KIT来确认乳腺细胞起源.

主要成果:

确定了一种非封装的,透的圆细胞瘤,具有非类型性和高线粒活性.
瘤细胞表现出与巨细胞一致的细胞内颗粒.
KIT IHC证实了乳腺细胞分化.
转移到区域淋巴结的转移表明恶性行为.

结论:

这一病例代表了蝙蝠中皮下巨细胞瘤的首次报告.
血清素蝙蝠中的MCT具有恶性潜力.
诊断可能需要特殊的染色和免疫组织化学,包括KIT IHC.
对蝙蝠中KIT IHC的预后价值进行进一步的研究是有必要的.

关键词:

埃普特斯科斯 (Eptesicus serotinus) 是一种有毒的植物.这是一款KIT KIT.免疫组织化学免疫组织化学巨细胞瘤是一个巨细胞瘤.血清素蝙蝠是一种蝙蝠.

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