尿中植物雌激素的升高与生物衰老的延迟有关:对NHANES数据的横截面分析
Jing Wang1, Qiancheng Cao1, Minjie Gao1
1Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University, Hangzhou, China.
Scientific reports
|March 13, 2025
概括
饮食中较高的植物雌激素摄入量与较慢的生物衰老有关. 这项研究表明,植物雌激素可能具有抗衰老作用,特别是质素,与加速衰老的几率较低有关.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 饮食中的植物雌激素是具有潜在健康益处的植物化合物.
- 它们对生物衰老的影响,这是与年龄相关疾病的关键因素,尚未完全理解.
- 了解植物雌激素在衰老中的作用,可以为预防性健康策略提供信息.
研究的目的:
- 研究尿液中植物雌激素水平与生物衰老指标之间的关联.
- 为了确定特定的植物雌激素 (异黄,质素) 是否对衰老标志物有差异性影响.
- 探索植物雌激素摄入量与加速衰老的几率之间的关系.
主要方法:
- 从国家健康和营养检查调查 (1999-2010年) 中对7981名成年人的横截面分析.
- 使用HPLC-tandemMS测量尿中的植物性雌激素 (异黄,质素).
- 从12个临床生物标志物计算生物年龄指标 (KDM-BA,PA,HD).
主要成果:
- 增加的总植物雌激素和质素与较慢的生物衰老标志物相关 (KDM-BA不太先进,PA和HD更先进).
- 较高的植物雌激素和质素水平显著与加速衰老的几率较低有关.
- 与质素相比,异黄与衰老标志物的关联较弱.
结论:
- 尿液中较高的植物雌激素水平与缓慢生物衰老的标志物有关.
- 饮食中的植物性雌激素消费可能会产生抗衰老作用.
- 需要进一步的纵向和干预研究来证实这些发现.
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