优化以乙醇改性超临界二氧化碳提取,以提高大麻种子油中生物活性化合物的回收率
Aymane Allay1, Chaymae Benkirane1, Abdessamad Ben Moumen1
1Laboratory of Agricultural Production Improvement, Biotechnology, and Environment, Faculty of Sciences, Mohammed I University, B.P. 717, 60000, Oujda, Morocco.
Scientific reports
|March 13, 2025
概括
使用乙醇进行超临界二氧化碳提取有效提高了大麻种子油产量和生物活性化合物. 在优化条件下,产油含有30.13%的富含和托科菲醇的油,适用于化品和制药应用.
科学领域:
- 食品科学与技术 食品科学与技术
- 自然产品化学 自然产品化学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 麻油富含有价值的化合物,但可以提高提取效率.
- 超临界流体提取 (SFE) 提供了一种绿色和高效的石油提取方法.
- 乙醇辅溶剂可以增强像醇这样的极性化合物的提取.
研究的目的:
- 通过响应表面方法来优化大麻种子油的超临界CO2提取.
- 研究乙醇辅溶剂对石油产量和生物活性化合物提取的影响.
- 为了识别和量化提取的麻油中的化合物.
主要方法:
- 超临界二氧化碳提取 (SFE) 与响应表面方法 (RSM) 进行过程优化.
- 温度,压力和时间的系统变化为SFE.
- 在超临界CO2中添加乙醇 (2.5-20%) 作为辅溶剂.
- 分析石油产量,总,多科菲醇,氧化稳定性和化合物 (HPLC-DAD/ESI-MS2).
主要成果:
- 优化的SFE条件 (50°C,20 MPa,244分钟) 产生了28.83%的油.
- 10%的乙醇辅溶剂显著增加了产油量,达到30.13%,总醇达到294.15毫克GAE/kg,多科菲醇达到484.38毫克/kg.
- 乙醇添加增强了26种化合物的提取,包括N-trans-caffeoyltyramine,大麻素A和B.
- 提取的油具有较好的氧化稳定性 (28.01小时).
结论:
- 用乙醇修改的超临界CO2提取是一种有效的方法,用于获得高质量的麻油.
- 增强油含有丰富的生物活性化合物和多科菲醇.
- 由于其特性,提取的麻油在化品,制药和食品行业具有潜在的应用.
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