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在马体中对2-基乙烯酸盐的活体代谢研究

Helen S M Ho¹, Adrian F Farrington², Emmie N M Ho³

¹Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong Special Administrative Region, China.

Drug testing and analysis

|March 13, 2025

概括

这项研究研究了马中的2-乙烯酸盐 (2HES) 的代谢,以检测其滥用. 2HES是最适合检测的标,在尿液中保持长达10天.

科学领域:

兽医药理学兽医药理学
药物新陈代谢药物新陈代谢
马体育医学马体育医学

背景情况:

2-基乙酸盐 (2HES) 是一种非类固醇抗炎药物 (NSAID),用于肌肉骨损伤.
在马中滥用2HES可以掩盖受伤并影响表现,造成健康风险,并导致马赛中的不良发现.
马的体内代谢和2HES的命运以前没有报道过.

研究的目的:

为了阐明2-乙烯酸盐 (2HES) 在马中的体内代谢.
确定最合适的生物标志物来检测2HES在马体育运动员中的使用.
为控制2HES在赛马中的滥用策略提供信息.

主要方法:

局部施用2HES凝给三个割马.
尿液和血样本的分析,以识别和量化2HES及其代谢物.
假定代谢物包括葡萄糖合2HES (2HES-Glu),硫酸合2HES (2HES-SO4) 和酸 (SA).

主要成果:

在注射后的10天内,在马类尿液中检测到总的2HES.
自由2HES在马类血中可检测到给药后16小时.
酸 (SA) 含量没有超过国际值,因此不适合监测2HES暴露.

结论:

2-基乙酸盐 (2HES) 是最适合用于检测其在马群中的使用的标.
检测尿液中的2HES总量为识别最近2HES使用提供了可靠的窗口.
监测SA对于检测2HES的滥用是不有效的,因为在给药后的度很低.

关键词:

2 - - 基乙醇盐酸盐酸.没有NSAID可以治疗.管理研究研究研究研究.马匹的兴奋剂控制是如何进行的

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