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在美国,暴露于制阻燃剂和高脂血症风险之间的关联. 大人的成年人
Junping Liu1, Zhaoyue Liu1, Xinru Liu1
1School of Health Management, Harbin Medical University, Harbin, China.
血清暴露于有毒的制阻燃剂 (BFRs) 与更高的超脂血症风险有关. 聚二乙烯 (PBDE) 和聚二 (PBB) 是最具影响力的,特别是PBDE209.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 对有毒制阻燃剂 (BFRs) 的环境暴露对人类健康构成风险.
- 血清BFR和高脂血症风险之间的关联需要进一步调查.
研究的目的:
- 确定血清BFRs对高脂血症风险的单个和综合影响.
- 为了确定最有影响力的BFRs导致高脂血症.
主要方法:
- 分析了来自NHANES (2007-2016) 的7009名个人数据.
- 使用多变量逻辑回归评估9种类型的血清BFR和超脂血症.
- 通过加权量子和 (WQS) 回归,量子g计算 (QGC) 和贝叶斯核机回归来评估累积的BFR效应.
主要成果:
- 包括PBDE和PBB153在内的8种BFR显示出与高脂血症风险的积极关联.
- WQS和QGC模型证实了BFR和超脂血之间的一致的正相关性.
- 确定PBDE209是最重要的化学物质,观察到剂量-反应关系.
结论:
- 血清BFR暴露,无论是单独的还是联合的,都与高脂血症风险的增加有关.
- 需要进一步的大规模队列研究来证实因果关系.
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