关于加纳抗生素耐药性基因的系统审查和元分析
Eric S Donkor1, Alex Odoom2, Abdul-Halim Osman2
1Department of Medical Microbiology, University of Ghana Medical School, Korle Bu, P. O. Box KB 4236, Accra, Ghana. esampane-donkor@ug.edu.gh.
BMC medical genomics
|March 13, 2025
概括
抗微生物耐药性基因在加纳的人类,动物和环境来源中共享. 这突显了耐药性的相互联系,以及需要采取多学科方法来打击抗菌素耐药性 (AMR).
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 抗生素耐药性 (AMR) 是一个重要的全球健康挑战,因为对抗生素耐药性基因 (ARG) 和其传播的理解有限.
- 调查加纳的ARG对于解决当地和全球AMR问题至关重要.
研究的目的:
- 系统地审查和对来自加纳的人类,动物和环境来源的细菌中ARG的流行情况进行元分析.
- 量化和估计特定ARG的流通情况.
主要方法:
- 在Web of Science,PubMed和Scopus数据库中的系统文献搜索,截至2024年2月25日.
- 使用纽卡斯尔-太华尺度 (NOS) 评估偏差风险.
- 描述性统计和数据解释的比例元分析.
主要成果:
- 38项研究符合纳入标准,涵盖了加纳的地理位置.
- 在ESBL基因的发病率: blaCTX-M (31.6%), blaTEM (19.5%), blaSHV (3.5%).
- 碳烯酶基因的发病率: blaNDM (17.2%),blaOXA (10.3%). 这两种基因的发病率都很高. 其他ARG如sul1,qnrS,gyrA,erm(B) 和mecA也被检测到.
结论:
- 来自加纳的人类,动物和环境来源的细菌共享ARG,表明相互联系.
- 横向基因转移促进ARG传播,强调需要一个健康的方法.
- 为了在加纳有效制抗药耐药性,一个多学科的战略是必不可少的.
关键词:
抗生素耐药性基因 (ARG) 是指抗生素耐药性的基因.抗微生物耐药性 (AMR) 是一种这里是加拿大加拿大加拿大加拿大.多种药物耐药性 (MDR)一个健康,一个健康.流行程度 流行程度系统性审查 系统性审查更多相关视频
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