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Updated: Jul 18, 2026

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延迟的病毒清除和改变的炎症反应会影响老年小鼠的SARS-CoV-2感染的严重程度

Émile Lacasse1,2, Isabelle Dubuc1, Leslie Gudimard1

  • 1Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier, Universitaire de Québec- Université Laval, Québec, QC, Canada.

Immunity & ageing : I & A
|March 13, 2025
PubMed
概括

衰老会损害免疫系统,导致更糟糕的COVID-19结果. 与年轻小鼠相比,老年小鼠的病毒清除减少,肺部损伤增加,抗病毒反应较弱.

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Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...