多种炎症生物标志物与患结石风险之间的关联
1Department of Urology, Nowon Eulji Medical Center, Eulji University, Seoul, South Korea. sinbanpolee@gmail.com.
BMC urology
|March 13, 2025
概括
像LMR,NLR和SII这样的炎症标记的升高与结石有关,特别是在50岁以上的个体中. 管理系统性炎症可能有助于预防老年人结石病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 炎症研究 炎症研究
- 公共卫生 公共卫生
背景情况:
- 结石 (结石) 影响全球9%,复发率为50%,影响生活质量和医疗费用.
- 系统性炎症被怀疑是结石的危险因素,但之前的研究面临了回忆偏差.
- 这项研究利用健康检查数据来调查炎症标志物和结石病之间的关联,而没有回忆偏差.
研究的目的:
- 为了确定炎症标志物是否在患有结石病和没有结石病的个体中存在差异.
- 评估特定的炎症标志物 (NLR,LMR,SII) 与结石的存在之间的关联.
- 通过年龄和性别分层调查这些关联.
主要方法:
- 韩国首尔31162名参与者的健康检查数据 (2010-2020年) 的分析.
- 包括427名通过KUB放射和超声波检测到结石 (结石>5毫米) 的参与者.
- 对炎症标志物 (NLR,LMR,SII) 的逻辑回归分析,对混因子进行调整,并按年龄和性别分层.
主要成果:
- 在女性中,低LMR,高NLR和高SII与结石有关.
- 在男性中,低LMR和高NLR与结石有关;SII没有显著意义.
- 这些关联仅在50岁或以上的参与者中显著,特别是在男女中LMR和NLR以及女性中SII.
结论:
- 炎症标志物升高与结石有显著的关联,特别是在50岁及以上的个体中.
- 系统性炎症似乎在石病原发生中起着关键作用,特别是在老年人群中.
- 研究结果表明,控制全身炎症可能对预防老年人结石至关重要.
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