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代谢表达特征分析显示,以酸盐为媒介的EPHB2上调促进了头部和部状细胞癌的淋巴转移

Jingjing Miao^1,2, Boyu Chen³, Lu Zhang^1,4

¹State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, P. R. China.

Journal of translational medicine

|March 13, 2025

概括

在头角状细胞癌 (HNSCC) 中的代谢重编程推动了淋巴转移. 酸盐的新陈代谢驱动EPHB2的上调,促进瘤淋巴血管生成和更糟糕的结果.

科学领域:

在瘤学瘤学.
代谢途径代谢途径
癌症转移癌症转移

背景情况:

淋巴转移是头部和部状细胞癌 (HNSCC) 死亡的一个关键驱动因素.
代谢重编程是癌症的标志,但其在HNSCC转移中的作用尚未完全理解.

研究的目的:

根据代谢基因表达来对HNSCC患者进行分类.
阐明在HNSCC中将代谢障碍与淋巴转移联系在一起的机制.

主要方法:

利用TCGA和GEO数据库通过代谢基因表达特征对HNSCC患者进行分类.
研究了酸盐代谢,EPHB2,EFNB1和YAP/TAZ信号在瘤淋巴血管生成中的作用.
评估了针对EPHB2和VEGFR3.3的组合治疗策略.

主要成果:

确定了与淋巴转移和不良预后相关的碳水化合物代谢亚组.
证明激活的pyruvate新陈代谢可提高EPHB2的调节,促进淋巴血管生成,独立于VEGF-C/VEGFR3.
发现了一种机制,其中核乙-CoA促进基因素乙化,上调EPHB2,然后影响YAP/TAZ和PROX1驱动淋巴血管生成.
表明结合EFNB1-Fc和VEGFR3抑制可以协同废除淋巴血管生成.

结论:

酸盐代谢是通过EPHB2.2在HNSCC中淋巴转移的关键驱动因素.
向EPHB2是一个潜在的治疗策略,特别是对于对VEGFR3抑制剂无反应的患者.

关键词:

EPHB2 EPHB2是什么意思头部和部状细胞癌瘤淋巴细胞生成 (Lymphangiogenesis) 是一种发生淋巴细胞的过程.淋巴细胞转移的转移.皮鲁酸盐的代谢过程

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