在炎症性肠道疾病中结肠炎相关的发育不良:特征和内镜管理
Sara C Schiavone1, Livia Biancone1, Mariasofia Fiorillo1
1Gastroenterological Unit, Department of Systems Medicine, University "Tor Vergata" of Rome, 00133 Rome, Italy.
Cancers
|March 13, 2025
概括
患有炎症性肠病 (IBD) 的患者面临着增加的结直肠癌风险. 早期检测和内镜切除失育症至关重要,像ESD这样的先进技术对困难的病变有希望.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 内視鏡外科手術 內視鏡外科手術
背景情况:
- 长期患有结肠炎症性肠病 (IBD) 的患者患结肠癌的风险较高.
- 大肠炎相关的癌症发生遵循一个"炎症 - - 癌症"序列,与零星结肠直肠癌的"腺瘤 - 癌症"路径不同.
研究的目的:
- 审查目前的内镜监测和治疗策略,以治疗IBD患者的结肠直肠功能障碍.
- 讨论IBD相关病变的内镜切除技术的挑战和进展.
主要方法:
- 标准化内镜监测使用染料喷雾和虚拟染色内镜用于早期诊断.
- 检测到的发育不良症的分类.
- 内镜切除技术包括多角切除,内镜粘膜切除 (EMR) 和内镜亚粘膜切除 (ESD).
主要成果:
- 大多数IBD相关的失塑性病变可以通过内镜切除来治疗,尽管由于纤维化和边缘定义问题,程序具有挑战性.
- 整体切除与较低的复发率有关,有利于ESD对较大的病变 (>20毫米).
- 像水下EMR/ESD这样的新技术可能会降低风险,并在IBD中扩展先进的内镜切除.
结论:
- 早期检测和分类的发育不良是IBD患者有效管理的关键.
- 内镜切除,特别是对较大的病变的ESD,至关重要,但需要进一步评估长期疗效.
- 对新型内镜技术的持续研究对于改善IBD患者的治疗结果至关重要,因为IBD患者的复发风险很高.
相关概念视频
01:21Inflammatory Bowel Disease V: Surgical Management
77
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
77
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
106
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
106
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
290
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
290
01:30Inflammatory Bowel Disease II: Crohn's Disease
151
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
151
01:17Chronic Bowel Disorders: Introduction
375
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
375
01:29Inflammatory Bowel Disease IV: Pharmacological Management
84
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
84