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Updated: May 22, 2025

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在细胞癌中血清miRNA的评估:系统性审查

Giovanni Cochetti¹, Liliana Guadagni¹, Alessio Paladini¹

¹Urology Clinic, Department of Medicine and Surgery, Santa Maria della Misericordia Hospital, University of Perugia, 06129 Perugia, Italy.

|March 13, 2025

概括

血清微RNAs (miRNAs) 显示出诊断细胞癌 (RCC) 的前景. 这次审查确定了像miR-210这样在RCC患者中发生变化的特定miRNA,这表明了潜在的非侵入性诊断标记.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

微RNAs (miRNAs) 越来越多地被认为在瘤疾病中的作用.
细胞癌 (RCC) 是一个重要的健康问题,需要新的诊断标志物.

研究的目的:

系统地审查和分析涉及细胞癌 (RCC) 的血清miRNAs.
评估循环miRNAs在非侵入性RCC检测中的诊断潜力.

主要方法:

在PROSPERO协议CRD42024550709.9.之后进行系统的文献审查.
在PubMed,EMBASE和Clinicaltrials.gov搜索了成人RCC患者和健康对照患者血清miRNA的研究.
包括26项研究在选500个记录后.

主要成果:

在RCC患者中,miR-210经常过度表达,尽管一项研究没有发现差异.
几种miRNAs,包括miR-1-3p和miR-129-5p,在RCC中持续下调.
其他miRNAs,如miR-221,miR-222,miR-224-5p和miR-1233在RCC患者中持续上调.

结论:

循环miRNAs为RCC诊断提供了一个有希望的,非侵入性的方法.
进一步的研究需要在更大的队列中进行标准化和验证.
开发多标记面板对于推进基于miRNA的RCC诊断至关重要.

关键词:

生物标志物生物标志物液体活检活检液体活检这是一个小RNARNA.这是一个微型RNA.细胞癌瘤是细胞癌.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...