人类乳头瘤病毒相关的皮肤状细胞癌
Alejandra Sandoval-Clavijo1,2, Ignasí Martí-Martí1,2, Carla Ferrándiz-Pulido3,4
1Department of Dermatology, Hospital Clínic de Barcelona, 08036 Barcelona, Spain.
Cancers
|March 13, 2025
概括
人类乳头瘤病毒 (HPV) 导致皮肤癌 (cSCC),特别是在免疫受损的个体. 这篇评论详细介绍了HPV的细节.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 人类乳头瘤病毒 (HPV) 与皮肤癌的发展有关,特别是在免疫抑制患者中.
- HPV coproteins E6 和 E7 可以使瘤抑制蛋白 p53 和 pRb 不活化,从而破坏细胞循环控制.
- 不同的HPV类型 (β和α) 在皮肤疾病中发挥着不同的作用,如表皮膜异位形成症和粘膜/皮肤病变.
研究的目的:
- 审查HPV的微生物学及其在皮肤状细胞癌 (cSCC) 代中的作用.
- 检查HPV相关的cSCC在免疫抑制个体,包括固体器官移植接受者的临床特征.
- 为HPV相关的cSCC提供基于证据的管理指南.
主要方法:
- 关于HPV微生物学,瘤发生和与cSCC的临床关联的文献综述.
- 对破坏宿主细胞循环调节的HPV上蛋白机制 (E6/E7) 的分析.
- 对免疫抑制患者和特定HPV类型中cSCC的临床数据的检查.
主要成果:
- 由于E6/E7蛋白质的介导,HPV的致癌潜力会使p53和pRb失活,从而导致细胞的不受控制的增殖.
- β-HPV类型与表皮质可变性形性表皮性质相关,而α类型引起皮肤和粘膜病理.
- 免疫抑制,特别是固体器官移植后的免疫抑制,显著增加了cSCC的风险和影响特征.
结论:
- HPV是cSCC致癌的一个重要因素,特别是在免疫受损的宿主中.
- 了解HPV类型,coprotein功能和临床表现对于管理cSCC至关重要.
- 与HPV相关的cSCC的管理准则应考虑宿主因素,瘤特征和新出现的治疗选择,包括疫苗.
更多相关视频
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.6K
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
相关概念视频
Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
Rous Sarcoma Virus (RSV) and Cancer
4.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
4.9K
Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
Cancer Vaccines
319
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
319
Mechanisms of Retrovirus-induced Cancers
5.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.0K
