在晚期泌尿腺癌中Avelumab维护疗法:时间和治疗顺序的影响
Lisa Gonçalves1, Helena Guedes2, Ana Raquel Fortuna3
1Department of Oncology, Unidade Local de Saúde Santa Maria Lisboa, Avenida Professor Egas Moniz, 1649-035 Lisboa, Portugal.
Cancers
|March 13, 2025
概括
晨间输注阿维卢马布可能会改善晚期泌尿器官癌患者的生存结果. 这项研究表明,早晨使用免疫检查点抑制剂可能有好处,需要进一步调查.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 尿癌研究 尿癌研究
背景情况:
- 以白金为基础的化疗,其次是阿维卢马布维护,是晚期泌尿腺癌 (aUC) 的标准治疗方法.
- 治疗的最佳顺序,特别是随着抗体药物联合体 (ADCs) 的出现,仍在研究中.
- 新出现的证据表明,免疫检查点抑制剂 (ICI) 给药时间可能会影响患者的治疗结果.
研究的目的:
- 评估aUC患者的avelumab维持治疗的安全性和临床结果.
- 评估阿维卢马布输液时间 (上午与下午) 对无进展生存 (PFS) 和整体生存 (OS) 的影响.
- 将结果与历史数据进行比较,包括JAVELIN Bladder 100试验.
主要方法:
- 在葡萄牙对105名用阿维卢马布治疗的患者进行了回顾性分析.
- 安全性,PFS,OS和整体响应率 (ORR) 的评估.
- 多变量分析,以评估输液时间对结果的影响.
主要成果:
- 随访时间中位数为17.7个月;中位数PFS为9.8个月,中位数OS为39.5个月.
- 免疫相关的不良事件 (irAEs) 在65.8%的患者 (6.7%的3级) 发生.
- 早晨的阿维卢马布输液与显著改善的OS (HR 0.35,p=0.042) 和改善PFS (HR 0.43,p=0.055) 的趋势有关.
结论:
- 阿维卢马布在aUC中证明了临床疗效和安全性,与JAVELIN Bladder 100相比,可能提供更好的结果.
- 早晨的阿维卢马布输液可能会提供生存益处.
- 需要进一步的研究来优化治疗顺序和输液时间在ICI策略中的作用.
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