大型肝脏手术后,虚弱是否与更糟糕的结果有关? 一个观察性病例控制研究
Sorinel Lunca1,2, Stefan Morarasu1,2, Andreea Antonina Ivanov1,2
12nd Department of Surgical Oncology, Regional Institute of Oncology (IRO), 700483 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|March 13, 2025
概括
虚弱预测严重肝脏手术后的肝功能衰竭等并发症,导致更长的ICU停留时间. 然而,在这项研究中,虚弱和非虚弱患者的整体死亡率和发病率相似.
科学领域:
- 肝胆道手术是肝胆道的手术.
- 手术瘤学手术瘤学
- 老年人手术是一项老年人手术.
背景情况:
- 肝脏手术患病率很高,可能超过30%,特别是在高风险患者群体中.
- 脆弱性评估对于预测手术结果至关重要,通过评估患者对手术压力的弹性.
研究的目的:
- 为了研究患有恶性瘤的肝切除术的患者的脆弱性和术后结果之间的关联.
- 用修改的脆弱指数 (mFI-5) 来比较脆弱和非脆弱患者之间的手术结果.
主要方法:
- 一个单中心的观察病例控制研究包括230名肝脏恶性瘤患者接受肝脏切除 (2013-2024年).
- 根据修改的脆弱指数 (mFI-5) 将患者分为脆弱 (n=140) 和非脆弱 (n=90) 的两类.
- 结果使用千平方和逻辑回归模型进行了分析.
主要成果:
- 虚弱患者的整体发病率较高 (p=0.04),但与非虚弱患者相比,死亡率和停留时间相似.
- 在主要的肝切除术中,脆弱的患者患有肝切除术后肝衰竭的几率增加 (LR 6.793,p=0.009),术后出血 (LR 9.541,p=0.002) 和更长的ICU停留 (LR 8.666,p=0.003).
- 胆汁泄漏率,手术部位感染,停留时间和死亡率在主要切除组之间是可比的.
结论:
- 虚弱性是肝切除术后肝衰竭和长时间ICU停留的重要预测因子,主要是肝切除的患者.
- 虽然虚弱与特定并发症有关,但在这个队列中,虚弱和非虚弱患者之间的整体死亡率和外科病率没有显著差异.
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