性别差异在正正静止血管硬度增加在年轻人对象
Victor N Dorogovtsev1, Dmitry S Yankevich1, Valentina M Tsareva2
1Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia.
Diagnostics (Basel, Switzerland)
|March 13, 2025
概括
与女性相比,男性的血管硬度呈现出更大的正静态增加,这是动态生物标志物所表明的. 早期发现血管硬对于预防年轻人患心血管疾病至关重要.
科学领域:
- 心血管生理学心血管生理学
- 血管生物学 血管生物学
- 预防性心脏病学 预防性心脏病学
背景情况:
- 在年轻人中早期发现血管硬是预防高血压和与年龄有关的心血管疾病的关键.
- 了解血管对静态应激反应的性别差异对于量身定制的预防策略至关重要.
研究的目的:
- 通过头向上倾斜测试 (HUTT) 来研究正静血管性的性别特异性.
- 评估血管储备的动态生物标志物,包括功能储备系数 (FRC).
主要方法:
- 133名健康的年轻成年人 (18-20岁;93名女性,40名男性) 接受了HUTT.
- 测量了手臂关节脉冲波速率 (baPWV) 和血压.
- 计算了正静态变化 (ΔbaPWV) 和FRC (ΔbaPWV/baPWVb).
主要成果:
- 基线baPWV显示没有性别差异.
- 在男性中,直立的HUTT baPWV (baPWVt),ΔbaPWV和FRC显著高于男性.
- 在p值:baPWVt (0.0007), ΔbaPWV (0.0009), FRC (0.0064). 在p值:
结论:
- 男人表现出比女性更强的动态血管应对静态压力的反应.
- 动态生物标志物 (ΔbaPWV,FRC) 显示了血管储备的显著性别差异.
- 需要进一步的研究来确定这些生物标志物的参考值,以评估血管衰老和预防性干预措施.
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