甲状腺功能测试与41周及以上怀孕的出生参数之间的关系:一项前性队列研究
Mustafa Can Sivas1, Karolin Ohanoglu Cetinel1, Ipek Emine Geyikoglu1
1Department of Obstetrics and Gynecology, Republic of Türkiye Ministry of Health, Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Türkiye.
Diagnostics (Basel, Switzerland)
|March 13, 2025
概括
甲状腺激素,特别是自由甲状腺素 (FT4),可能与晚期怀孕中的胎儿痛苦和新生儿体重有关. 较低的FT4水平与新生儿体重增加和更高的胎儿痛苦风险相关.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 围产儿医学 围产儿医学
背景情况:
- 有限的研究存在于甲状腺激素在晚期怀孕 (≥41周) 和关键产科结果之间的关联.
- 研究这些关系对于理解潜在的风险和优化晚期孕期的母胎护理至关重要.
研究的目的:
- 为了检查甲状腺激素 (TSH,FT4) 和分娩时间,分娩时间,胎儿痛苦,PROM和母体血图之间的相关性.
- 为了比较41周以上的怀孕 (晚期) 和37-38周的怀孕 (对照) 之间的这些参数.
主要方法:
- 一组68名无孕妇女被分为晚期组 (≥41周,n=37) 和对照组 (37-38周,n=31).
- 测量了甲状腺激素 (TSH),自由甲状腺素 (FT4),血红蛋白和血红素水平.
- 分析了包括出生类型,分娩持续时间,胎儿痛苦,PROM和分娩后血图变化在内的结果.
主要成果:
- 较低的FT4水平与胎儿痛苦 (p < 0.05) 和与新生儿体重 (p < 0.05) 的负线性关系有显著的关联,这表明更高的体重与较低的FT4.4有关.
- 在TSH/FT4值,出生类型,分娩持续时间或分娩后血图变化 (p > 0.05) 之间没有发现显著差异.
- 在TSH/FT4和PROM,分娩时间或血液图变化 (p > 0.05) 之间没有观察到显著的关系.
结论:
- 甲状腺激素水平 (TSH / FT4) 可能在怀孕的成熟和晚成熟阶段发挥作用.
- FT4水平显示出与胎儿痛苦风险,出生类型和新生儿体重的潜在关联.
- 需要进一步的研究来阐明这些发现在晚期怀孕中的临床意义.
相关概念视频
01:18Functions of Thyroid Hormones
2.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.4K
01:20Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
01:07Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
01:24Gonadal and Placental Hormones
1.3K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.3K
01:20Pathophysiology of Diabetes
839
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
839
01:23The Thyroid Gland
3.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.4K