阿加尔/β-环极烯复合型冷凝用于控制释放阿里皮普拉
Siyka Stoilova1, Georgy L Georgiev1, Rositsa Mihaylova2
1Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Molecules (Basel, Switzerland)
|March 13, 2025
概括
新的阿加和β-环德林冷凝改善了阿里皮普拉 (ARZ) 的输送. 这些基于天然产品的系统增强了药物的溶解性,并显示了pH依赖的释放,为ARZ配方提供了有前途的方法.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 阿里皮普拉 (ARZ) 是一种必要的非典型抗精神病药物,用于治疗各种精神疾病.
- 由于ARZ的水溶性较差,限制了其治疗效果,需要先进的药物输送系统.
- 天然产品,如阿加和β-环极 (CD) 提供了开发新药载体的潜力.
研究的目的:
- 开发和评估新型的冷凝药物输送系统,用于阿里皮普拉 (ARZ) 使用阿加和β-环氧 (CD).
- 调查开发的ARZ加载冷凝的物理化学特性和药物释放特征.
- 评估这些冷凝对改善ARZ溶解性和生物可用性的潜力.
主要方法:
- 低温凝是通过对水性和β-环氧/ARZ复合溶液进行冷处理制造的,然后经过解.
- 鉴定包括评估凝分数,胀程度,毛孔体积,弹性特性和形态.
- 实验室药物释放研究是在模拟的胃 (pH 1.2) 和肠道 (pH 6.8) 中进行的.
主要成果:
- 复合型冷凝表现出理想的物理化学特性,适合药物输送.
- 阿里皮普拉的释放表现出依赖pH值的行为,在酸性条件下释放速度显著减慢.
- 在48小时内,在体外条件下,大约33%的装载ARZ被释放.
结论:
- 基于和β-cyclopodextrin的冷凝是aripiprazole的一种可行的药物输送系统.
- 开发的冷凝显示出增强ARZ溶解度和控制其释放特征的潜力.
- 这种天然产品衍生系统为改善阿里皮普拉的治疗效果提供了一个有前途的平台.
更多相关视频
08:39Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
8.9K
08:59A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
17.3K
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
332
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
332
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137
01:22Modified-Release Drug Delivery Systems: Drug Release Characteristics
257
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
257
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
172
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
172
01:26Oral Drug Delivery Systems: Continuous-Release Systems
308
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
308
01:11Oral Drug Delivery Systems: Delayed-Release Systems
222
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222