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Updated: May 22, 2025

Discovery of New Intracellular Pathogens by Amoebal Coculture and Amoebal Enrichment Approaches
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通过基于结构的虚拟查,发现2-乙胺[d]thiazol-6-yl) -2-phenoxyacetamide衍生物作为新型潜在的BCR-ABL1抑制剂

Shuaixing Wang1, Minyi Wang1, Zi Li1

  • 1National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Reference and Research on Influenza, Key Laboratory for Medical Virology and Viral Diseases, National Health Commission, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing 102206, China.

Molecules (Basel, Switzerland)
|March 13, 2025
PubMed
概括

研究人员发现了新的BCR-ABL1抑制剂,包括10m化合物,用于对抗慢性髓性白血病 (CML). 这些新型化合物表现出抗瘤作用,并与阿西米尼布协同作用,为抗药性提供了希望.

关键词:
在 BCR-ABLL 中.组合疗法治疗组合治疗.结构活动关系结构活动关系

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