皮克林基于乳液的凝,用化作为稳定剂:配方,机械性能和体外药物释放研究
13D Printing Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.
Molecules (Basel, Switzerland)
|March 13, 2025
概括
这项研究开发了用可因加载的皮克林乳液,由化酸纳米管稳定,将其转化为半固体凝. 配方成分显著影响凝特性和利多卡因的释放,这表明局部缓解疼痛的潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 利多卡因是局部用于小手术和神经病痛的关键止痛药.
- 开发稳定有效的专题配方仍然是一个挑战.
研究的目的:
- 为了配制和表征带有利多卡因的皮克林油入水 (O/W) 乳液,该乳液由化纳米管稳定.
- 将这些乳液转化为半固体凝,并评估它们的物理化学和药物释放特性.
- 通过设计质量 (QbD) 方法探索配方参数对凝特性和利多卡因输送的影响.
主要方法:
- 使用化纳米管作为稳定剂制备皮克林o/w乳液.
- 将利多卡因纳入乳液的内部油阶段.
- 使用Poloxamer 407.7将乳液转化为半固体凝.
- 评估凝的质和纹理特性.
- 使用垂直弗朗茨扩散细胞评估利多卡因释放动力学.
主要成果:
- 乳液滴滴大小主要受到油和化物含量的影响.
- 凝产量应力,硬度和凝聚力随着油含量增加而增加.
- 利多卡因释放率主要受到活性成分在油阶段的度的影响.
结论:
- 哈洛西特纳米管有效地稳定了载有利多卡因的皮克林乳液.
- 配方成分对产生的半固体凝的气质,纹理和药物释放特征产生重大影响.
- 开发的凝显示了在疼痛管理应用中有效的局部利多卡因输送的潜力.
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