恶性转化和非转化口腔白血病在代谢上是不同的
Roberta Rayra Martins-Chaves1,2, Victor Coutinho Bastos2, Jéssica Gardone Vitório2
1Graduate Program in Health Sciences, Faculty of Medical Sciences of Minas Gerais (FCMMG), Alameda Ezequiel Dias, 275, Belo Horizonte 30130-110, Minas Gerais, Brazil.
International journal of molecular sciences
|March 13, 2025
概括
代谢学可以区分恶性口腔白血病 (MT-OLK) 和非转化口腔白血病 (NT-OLK). 在MT-OLK中的关键脂质变化可能作为口腔状细胞癌 (OSCC) 发展的早期生物标志物.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 口腔状细胞癌 (OSCC) 诊断依赖于了解早期的分子变化.
- 在健康组织,口腔白血病 (OLK) 和OSCC之间,代谢特征有所不同.
- 恶性转化OLK (MT-OLK) 和非转化OLK (NT-OLK) 之间的代谢区别尚不清楚.
研究的目的:
- 为了研究MT-OLK和NT-OLK之间的代谢差异.
- 确定在OLK中恶性转变的预测性分子生物标志物.
- 探索与口腔致癌相关的失调的代谢途径.
主要方法:
- 使用非向的高性能液态染色体质谱法 (HPLC-MS) 来分析代谢特征.
- 统计分析和生物信息学方法确定了歧视性化合物.
- 途径丰富分析阐明了失调的代谢途径.
主要成果:
- 17个分子特征,主要是脂质 (脂质,氧化脂质,胆固醇,脂肪酸),在MT-OLK和NT-OLK之间进行了区分.
- 在脂质代谢中观察到显著的变化,包括脂肪酸合成/降解,类固醇激素生物合成和甘油脂代谢.
- 预测模型在将MT-OLK与NT-OLK区分时获得了高准确度 (AUC = 0.88).
结论:
- 代谢学可以将MT-OLK与NT-OLK区分开来,识别口腔癌的潜在早期生物标志物.
- 脂质代谢失调与口腔白血病恶性转变有关.
- 为了临床应用,需要在更大的队列中进一步验证.
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