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Updated: Jun 30, 2026

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艾滋病毒患者的心血管疾病:对当前知识和临床影响的全面审查
Sorina Șoldea1, Maria Iovănescu1, Mihaela Berceanu1
1Department of Cardiology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania.
International journal of molecular sciences
|March 13, 2025
概括
人类免疫缺陷 (HIV) 患者的心血管疾病 (CVD) 越来越多地被认可,因为预期寿命更长. 慢性炎症和自身免疫有助于心血管疾病的风险,尽管在治疗方面取得了进展.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 人类免疫缺陷 (HIV) 患者的预期寿命改善,使得人们的注意力转向了对心血管健康的长期影响.
- 虽然由于高活性抗逆转录病毒疗法 (HAART) 的存在,感染性和艾滋病相关的并发症已经减少,但慢性炎症和自身免疫力仍然是一个重大问题.
研究的目的:
- 审查有关艾滋病毒患者心血管疾病 (CVD) 患病率,诊断和独特特征的当前文献.
- 检查蛋白酶抑制剂 (PI) 和辅助疗法在艾滋病毒相关心血管疾病中的作用.
- 了解在HAART时代向更慢性心血管表现的转变.
主要方法:
- 关于艾滋病毒患者心血管疾病当前研究的文献综述.
- 对研究的分析,重点关注患病率,诊断和独特的心血管疾病特征.
- 包括用蛋白酶抑制剂和补充疗法治疗的患者的数据.
主要成果:
- 在HAART的进步已经减少了传染病理,但持续的慢性炎症和自身免疫有助于增加心血管疾病的风险.
- 炎症标志物 (高灵敏度C反应蛋白,细胞因子) 的升高是常见的,促进内皮功能障碍,凝血障碍和加速动脉生成.
- 艾滋病毒患者现在表现出更多的慢性和阴险的心血管表现.
结论:
- 尽管预后有所改善,心血管疾病仍然是艾滋病毒患者的关键问题,其特点是慢性炎症和加速动脉动脉生成.
- 艾滋病毒中心血管疾病的临床表现已经发展,需要持续监测和管理策略,以适应这些慢性表现.
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