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克洛托蛋白水平对肥胖和肉症的影响:系统性审查

Diana G Ariadel-Cobo^1,2, Brisamar Estébanez¹, Elena González-Arnáiz^1,2

¹Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain.

International journal of molecular sciences

|March 13, 2025

概括

克洛托水平与肥胖和代谢综合征有关. 运动和饮食等干预措施改善了Klotho,可能成为这些疾病和心血管风险的生物标志物.

科学领域:

内分泌学和新陈代谢学
衰老研究研究衰老研究
遗传学和分子生物学

背景情况:

克洛托基因及其蛋白质产物 (α-klotho,β-klotho,γ-klotho) 已因其抗衰老特性和调节酸盐和激素代谢的作用而得到认可.
α-klotho存在于膜结合和分泌形式,与FGF23和其他FGF相互作用,而β-klotho在肌肉新陈代谢中至关重要,并与sarcopenic肥胖症有关.
克洛托的失调与类似衰老的表型和各种代谢障碍有关.

研究的目的:

与正常体重的个人相比,系统地审查和评估超重,肥胖或肥胖症的成年人中的Klotho水平.
评估Klotho水平与肥胖,代谢综合征 (MS) 和心血管风险之间的关联.
研究运动和饮食干预措施对Klotho水平的影响.

主要方法:

在PROSPERO注册的系统审查,遵守PRISMA指南.
从713篇文章的初始搜索中包括20项研究 (观察性,横截面,队列,临床试验).
在不同体质指数 (BMI) 类别和对干预措施的反应中比较Klotho水平.

主要成果:

在较低的Klotho水平与肥胖,代谢综合征 (MS) 和心血管风险增加之间观察到显著的关联.
运动和饮食干预措施表明对Klotho水平有积极的影响.
克洛托水平升高与肌肉强度的提高和衰减速度的减缓有关.

结论:

克洛托是肥胖症,多发性硬化症和肉骨肥胖症的潜在生物标志物.
针对生活方式修改的干预措施可以积极影响Klotho水平.
需要进一步的研究来阐明Klotho在代谢和与衰老相关的疾病中的精确机制和治疗潜力.

关键词:

联邦政府财政基金.克洛托 (Klotho) 是一个古老的语言.脂肪组织的脂肪组织.炎症导致的炎症.萨尔科佩尼克肥胖症肥胖症

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