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探索纳米交付系统,以提高埃达拉沃恩在肌缩侧面硬化症治疗中的性能

Brandon Aguiar^1,2,3, Ana Rita Alfenim¹, Cláudia Sofia Machado¹

¹CIQUP-IMS, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R.Campo Alegre s/n, 4169-007 Porto, Portugal.

International journal of molecular sciences

|March 13, 2025

概括

纳米配方提供了一个有前途的解决方案,通过提高稳定性和封装来提供埃达拉,一种肌缩侧面硬化症治疗方法. 稳定的聚合物和混合纳米粒子显示出ALS治疗的潜力.

科学领域:

制药科学制药科学
纳米技术纳米技术
神经科学是一个神经科学.

背景情况:

埃达拉是一种肌缩侧面硬化症 (ALS) 治疗方法,由于血液-大脑屏障的穿透性较差,寿命短,以及因分体化引起的不稳定性,疗效有限.
开发稳定的药物输送系统至关重要,以克服EDARAVONE对有效的ALS治疗的局限性.

研究的目的:

评估各种纳米配方 (聚合物,脂质聚合物混合物,脂质) 用于封装edaravone.
评估化和不同pH值对纳米粒子特性和稳定性的影响.
为了研究edaravone载荷纳米配方的细胞毒性.

主要方法:

在聚合物,脂质聚合物混合体和脂质纳米颗粒中封装埃达拉.
使用聚乙烯糖醇 (PEG) 或多科菲醇聚乙烯糖醇糖酸盐 (TPGS) 的功能化.
聚合物纳米颗粒在pH值7.4,9和11的制备;超过80天的稳定性评估;SH-SY5Y细胞系的细胞毒性测试.

主要成果:

在聚合物,脂质聚合物混合体和脂质纳米颗粒中成功封装edaravone.
在合成中较高的pH值降低了纳米粒子尺寸,提高了封装效率,但降低了稳定性.
聚合物和混合纳米粒子在4°C下80天表现出良好的稳定性;纳米结构脂质载体显示出细胞毒性.

结论:

埃达拉可以有效地封装在各种纳米载体中,增强其对ALS治疗的潜力.
稳定的聚合物和混合纳米粒子代表了edaravone输送的可行替代方案.
对纳米配方优化的进一步研究是有必要的,以改善ALS患者的治疗结果.

关键词:

骨髓缩侧面硬化症 (ALS) 是一种埃达拉沃尼是一个人混合纳米粒子的混合纳米粒子.纳米结构脂质载体纳米结构脂质载体

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