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Updated: May 22, 2025

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选择性3MST抑制剂I3MT-3作为一种强大的卡斯巴酶-1抑制剂起作用

Kohei Otani1, Ryuto Komatsu1, Takuya Noguchi1

  • 1Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.

International journal of molecular sciences
|March 13, 2025
PubMed
概括

I3MT-3通过直接向caspase-1而不是酶3-MST来抑制炎症和热. 这种化合物显示出作为治疗炎症疾病的卡斯巴酶-1抑制剂的潜力.

关键词:
抗炎药物是一种抗炎药物.卡斯帕斯-1酶是一种炎症酶体 (inflammasomes) 是一种炎症酶体.

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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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