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患有自闭症谱系障碍的儿童的尿道代谢概况

Joško Osredkar^1,2, Kristina Kumer¹, Uroš Godnov³

¹Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

International journal of molecular sciences

|March 13, 2025

概括

患有自闭症谱系障碍 (ASD) 的儿童表现出改变的甲代谢,TRP水平较高,KYN/TRP比率趋势较高. 这些代谢变化可以作为ASD严重程度的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
代谢学代谢学代谢学
生物化学生物化学

背景情况:

自闭症谱系障碍 (ASD) 与托 (TRP) 代谢中断有关.
来自TRP的关键神经活性代谢物可能会在ASD中受到影响.
研究这些途径可以确定ASD严重程度和进展的生物标志物.

研究的目的:

调查ASD儿童和健康兄弟姐妹之间尿液托芬代谢物的差异.
探索TRP代谢比率作为ASD严重程度的生物标志物的潜力.

主要方法:

使用液体染色体质谱法 (LC-MS/MRM) 量化尿中TRP代谢物.
使用Advia 2400分析仪 (Jaffe反应) 分析尿氨酸.
与ASD和对照组之间的代谢物水平和比率进行比较,并与CARS分数相关联.

主要成果:

与对照组相比,患有自闭症儿童的尿液TRP度明显高 (p=0.04).
在ASD组中观察到更高的Kynurenine (KYN) /TRP比率和改变的TRP/IAA和TRP/5-HIAA比率的趋势.
这些变化的比率与ASD症状严重程度存在相关性.

结论:

研究结果表明,在患有自闭症的儿童中,托芬代谢发生改变.
涉及TRP代谢物的代谢比率可能具有作为ASD的诊断或严重程度指示工具的潜力.
需要进一步的研究来验证这些发现及其临床实用性.

关键词:

汽车汽车的汽车.自闭症谱系障碍自闭症谱系障碍这种药物是kynurenine.托芬三聚氨酸是什么

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