基于血液的DNA甲基化生物标志物用于识别心血管疾病的风险和进展
Tarryn Willmer1,2,3, Lawrence Mabasa1,2, Jyoti Sharma1
1Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa.
International journal of molecular sciences
|March 13, 2025
概括
像DNA甲基化这样的表观遗传变化可能是早期心血管疾病 (CVD) 风险的信号. 基于血液的表观遗传标记显示出早期心血管疾病检测和预测个体治疗反应的前景.
科学领域:
- 生物医学科学 生物医学科学
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 非传染性疾病 (NCD) 是全球主要的死亡原因,心血管疾病 (CVD) 占NCD死亡人数的50%.
- 心血管疾病的发病可能会在临床症状之前出现,因此需要对早期干预的潜在分子变化进行研究.
- 表观遗传修饰,特别是DNA甲基化,作为遗传,环境和疾病表型之间的关键联系.
研究的目的:
- 审查当前关于血液基DNA甲基化变化的文献,以及它们与人类心血管疾病的关联.
- 确定有希望的差异甲基化基因作为潜在的CVD诊断和预后生物标志物.
- 讨论CVD中DNA甲基化研究的局限性和未来方向.
主要方法:
- 对研究DNA甲基化和心血管疾病的文献综述.
- 对涉及心血管疾病发病因子的不同甲基基因的分析.
- 综合有关DNA甲基化在早期心血管疾病事件中的作用的发现.
主要成果:
- 许多研究表明,在心血管疾病发育的早期阶段,DNA甲基化.
- 特定的差异甲基化基因显示出作为血液基生物标志物的潜力,用于CVD诊断和预后.
- 无症状个体的表观遗传查可能有助于早期发现心血管疾病和预测治疗反应.
结论:
- 基于血液的DNA甲基化变化越来越被认为在心血管疾病的发病过程中很重要.
- 为了验证CVD生物标志物候选人,需要在多种人群中进行进一步的研究和复制.
- 解决方法上的局限性对于推进基于DNA甲基化的CVD诊断和治疗至关重要.
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