装载着皮罗西卡姆的纯净和化布鲁希特水泥,用于长时间和持续的药物释放
Marcella Bini1,2, Giovanna Bruni1,2, Michela Sturini1,2
1Chemistry Department, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy.
Materials (Basel, Switzerland)
|March 13, 2025
概括
酸水泥 (CPCs) 在肌肉骨疾病方面表现有前途. 用或改进的机械性能和药物释放动力学,提供增强骨再生疗法的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 药物输送系统 药物输送系统
背景情况:
- 肌肉骨疾病由于预期寿命的延长而增加.
- 酸水泥 (CPCs) 由于其生物活性和再吸收,对治疗这些疾病充满希望.
- 然而,CPC在机械性能方面存在局限性.
研究的目的:
- 为了合成纯净和合的布鲁希特基CPC,加载Piroxicam.
- 研究 (Ba) 和 (Si) 兴奋剂对CPCs物理化学和制药性质的影响.
- 评估浸入酸盐缓冲剂对这些特性和药物释放的影响.
主要方法:
- 合成纯净的,化的和化的布鲁希特基CPCs.
- 在水泥配方中加入皮罗西卡姆.
- 在浸入酸盐缓冲剂之前和之后的物理化学性质的表征.
- 随着时间的推移评估皮罗西卡姆释放动力学.
主要成果:
- 皮罗西卡姆在硬化的水泥中过渡到无形状态.
- 补充剂 (Ba,Si) 没有改变布鲁希特的结构或形态.
- 与纯CPC相比,Ba和Si兴奋剂增强了初始Young的模量,而压力强度则降低了.
- 沉浸在缓冲器中降低了压力强度和弹性模量,随着时间的推移稳定.
- 皮洛西卡姆的完全释放发生在7天内,对于Ba-doped水泥而言,其动力学较慢.
结论:
- 和的兴奋剂可以调节基于布鲁希特的CPCs的机械性能.
- 兴奋剂影响药物释放特征,可能提供受控释放的优势.
- 这些修改后的CPC显示出改善骨再生和药物输送的治疗应用的潜力.
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