通过调节肠道微生物群和代谢物,L-阿拉比诺斯减轻了小鼠的功能性便秘
Ke Liu1, Huixuan Dong1, Xinran Li1
1State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
Foods (Basel, Switzerland)
|March 13, 2025
概括
通过改善肠道运动性,屏障功能和微生物群组成,L-阿拉伯有效地缓解了小鼠的功能性便秘. 这项研究强调L-阿拉伯作为促进肠道健康和缓解便秘的有希望的成分.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 微生物学 微生物学
背景情况:
- 功能性便秘是一种常见的健康障碍,其原因复杂.
- 作为一种天然粉素的L-阿拉伯,已知具有代谢和抗炎功效.
- 在治疗功能性便秘时,L-阿拉比诺的具体机制尚不清楚.
研究的目的:
- 在小鼠模型中研究L-阿拉比诺斯在缓解由二氧酸盐诱导的功能性便秘方面的疗效.
- 阐明L-阿拉伯对胃肠道系统产生影响的潜在机制.
主要方法:
- 在小鼠中使用diphenoxylate诱导功能性便秘.
- 给予不同剂量的L-阿拉比诺斯和乳糖 (阳性对照).
- 评估排便参数,肠道过渡,蛋白质表达 (AQP3,AQP4,ZO-1,Claudin-1,Occludin),激素和神经递质水平 (5-HT,VIP,MTL,气体),组织病理学,16SrRNA测序和代谢学.
主要成果:
- 氨酸显著减少了第一次黑色便的排便时间,并增加了便中的水含量.
- 它增强了小肠的推进力,并改善了紧密结合蛋白的表达,同时减少了水道蛋白.
- 氨酸调节了关键的消化荷尔蒙和神经递质,减少了炎症,并积极改变了肠道微生物群的组成和代谢物.
结论:
- L-阿拉伯在缓解功能性便秘方面表现出显著的潜力.
- 它通过增强胃肠道运动,改善肠道屏障功能和调节肠道微生物群来起作用.
- L-阿拉伯是一种有希望的功能成分,可以促进消化系统的健康.
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
124
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
124
Drugs Affecting GI Tract Motility: Other Laxatives
143
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
143
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
168
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
168
Drugs for Treatment of Diarrhea-Predominant IBS
133
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
133
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
160
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
160
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
153
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
153


