身体质量指数和心血管风险标记:大规模人口分析
Bela F Asztalos1, Giuseppina Russo2, Lihong He1
1Boston Heart Diagnostics, 200 Crossing Blvd, Suite 200, Framingham, MA 01702, USA.
Nutrients
|March 13, 2025
概括
维持正常的体重指数 (BMI) 对心血管健康至关重要. 体重指数升高,即使在正常范围内,也与动脉样硬化心血管疾病 (ASCVD) 风险因素的不良变化有关,无论年龄如何.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 体重指数 (BMI) 升高现在是动脉样硬化心血管疾病 (ASCVD) 风险评估的一个因素.
- 了解BMI和ASCVD风险因素之间的联系对于预防至关重要.
研究的目的:
- 研究BMI与各种传统和非传统的ASCVD风险因素之间的关联.
- 要确定这些关联是否依赖于年龄.
主要方法:
- 分析血糖,胰岛素,脂质,脂蛋白,固醇,脂肪酸,炎症标志物,氧化应激标志物和激素.
- 数据来自226,000名中年和老年受试者,分为五个BMI组 (20-25,25.1-30,30.1-35,35.1-40,和>40公斤/米2).
主要成果:
- 增加的BMI与大多数ASCVD风险标志物的不利变化有关,除了LDL-C.
- 随着BMI的上升,观察到高灵敏度C反应蛋白和胰岛素的显著增加.
- 随着BMI的增加,HDL-C和其他保护性大型HDL颗粒的减少,即使在正常体重范围内也是如此.
结论:
- 高BMI独立地与所有年龄组的ASCVD风险因素的不良变化有关.
- 通过生活方式或药物治疗维持正常的BMI对于预防ASCVD至关重要.
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