驼牛奶蛋白通过调节肠道微生物群和氨基酸代谢来改善性结肠炎
Ning Kang1,2,3, Zhexin Fan1,2,3,4, Li Yang5
1Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co-Construction by Ministry and Province), School of Food Science and Technology, Shihezi University, Shihezi 832000, China.
驼牛奶脂肪球膜蛋白 (MFGMP) 缓解了小鼠性结肠炎 (UC) 的结肠炎症. MFGMP调节肠道微生物群和氨基酸代谢,具有治疗炎症性肠道疾病的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 牛奶脂肪球膜 (MFGM) 显示出抗炎性质.
- 在像性结肠炎 (UC) 这样的炎症状况中,MFGM蛋白 (MFGMP) 的特定作用尚未得到充分研究.
研究的目的:
- 在小鼠模型中研究驼MFGMP对硫酸 (DSS) 诱导的UC的保护作用.
- 阐明潜在的机制,包括对肠道微生物群,代谢物和信号通路的影响.
主要方法:
- 将驼MFGMP (50 mg/kg) 给患有DSS诱导的UC的小鼠.
- 评估结肠炎症,细胞因子水平 (IL-6,IL-1β,TNF-α,IL-10),肠道微生物群组成,便代谢物 (氨基酸) 和Wnt/β-catenin通路基因表达 (WNT-1,β-catenin,Cyclin D1).
主要成果:
- 在DSS诱导的UC小鼠中,MFGMP显著降低了结肠炎症和病理损伤.
- MFGMP调节了肠道微生物群,增加了阿尔法多样性和有益的细菌,如*Lactobacillus*,同时减少了*Akkermansia*.
- MFGMP治疗使L-valine正常化,并增加了L-leucine,L-lysine,L-tyrosine和L-tryptophan水平,这与抗炎性标志物相关.
- MFGMP下调了Wnt/β-catenin通路组件 (WNT-1,β-catenin,Cyclin D1),表明该通路的调节.
结论:
- 驼MFGMP在小鼠中显示出对DSS诱导的UC具有显著的保护作用.
- 这些好处归因于肠道微生物群的调节,氨基酸代谢的恢复和Wnt/β-catenin通路的调节.
- 驼MFGMP作为治疗肠道炎症疾病的治疗剂具有前途.
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