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功能障碍中的基因生活方式相互作用:通过植物性饮食,咖啡摄入量和生物活性化合物相互作用来调节多基因风险
Meiling Liu1, Da-Sol Kim2, Sunmin Park2
1Department of Chemical Engineering, Shanxi Institute of Science and Technology, Jincheng 048011, China.
Nutrients
|March 13, 2025
概括
功能障碍的遗传风险受饮食和维生素D的影响.植物性饮食,咖啡和维生素D可能会降低遗传敏感个体的功能障碍风险.
科学领域:
- 遗传学和基因组学 在
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 研究的基因变异与估计的膜过率 (eGFR) 相关.
- 评估了遗传因素,生活方式和生物活性化合物之间的相互作用.
- 在大型医院队列中检查了对功能障碍风险的影响.
研究的目的:
- 确定与EGFR和功能障碍相关的遗传变异.
- 分析遗传风险得分,饮食和营养摄入量之间的相互作用.
- 确定生活方式和生物活性化合物对病遗传倾向的影响.
主要方法:
- 根据eGFR将参与者分为高GFR (控制) 和低GFR (功能障碍) 组.
- 进行全基因组关联分析以确定遗传变异.
- 为了生活方式的相互作用,利用了通用的多因素维度减小 (GMDR),并检查了与营养摄入的多基因风险得分 (PRS).
主要成果:
- 低的eGFR与西方饮食,和脂肪,氨酸和异氨酸摄入量有关.
- 在能源生产和氨基酸代谢途径中发现的关键遗传变异 (例如rs1047891_CPS1).
- 高PRS增加了低EGFR风险;PRS与植物性饮食和咖啡摄入量相互作用,降低了风险. 维生素D摄入量与CPS1 rs1047891相互作用,在摄入量足够的情况下降低风险.
结论:
- 对功能障碍的遗传倾向可以通过饮食和生活方式因素来改变.
- 植物性饮食,适度饮用咖啡和充足的维生素D摄入量对具有高遗传风险的个体有潜在的益处.
- 有证据支持基因-营养物相互作用,特别是涉及维生素D和CPS1,调节功能.
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