在接受体外膜氧化支持的患者中,COVID后的症状负担:潜在的2年随访分析
Rayan Cheaban1, Anna L Rogge1, Katharina E Schaeper2
1Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany.
The International journal of artificial organs
|March 13, 2025
概括
通过体外膜氧化 (ECMO) 治疗的COVID-19患者的两年随访显示结果稳定或有所改善. 然而,显著的长期认知,心理和社会障碍仍然存在,需要进一步研究以获得最佳恢复.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 严重的COVID-19后需要体外膜氧化 (ECMO) 的长期后果并没有得到很好的描述.
- 这项研究重点关注ECMO治疗COVID-19幸存者的2年随访数据.
研究的目的:
- 系统地描述使用ECMO治疗的COVID-19幸存者的长期心肺,神经认知,心理和功能状态.
- 在ECMO后2年评估与健康相关的生活质量 (HRQL).
主要方法:
- 研究了2020年4月至2021年9月期间需要ECMO的60名COVID-19患者的队列.
- 2年后通过电话和邮件使用经过验证的工具进行了后续评估.
- 出院后和6个月后的生存率分别为40.0%和33.3%.
主要成果:
- 19名幸存者 (平均年龄为57.0岁,21.1%为女性) 参与了为期2年的随访.
- 心肺状况普遍令人满意 (78.9%的NYHA类 I-II),84.2%的人在日常生活中独立.
- 显著的损伤包括认知缺陷 (47.4%),中度至重度抑郁 (15.8%),以及创伤后应激障碍症状 (15.8%).
- HRQL子标尺保持稳定,但整体自我评价健康状况有所改善 (p=0.04).
- 就业率上升,但社会生活仍然受到影响.
结论:
- 与6个月数据相比,COVID-19 ECMO幸存者的两年结果显示稳定或改善.
- 尽管有所改善,但长期的后果会影响生活的多个领域,包括认知和心理健康.
- 进一步描述长期COVID和ECMO后的后续情况对于改善患者康复至关重要.
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