在心血管系统中单维血流建模. 从传统的生理学设置到现实生活中的血液动力学
Pablo J Blanco1,2, Lucas O Müller3
1Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
概括
本综述探讨了全身血流模型,强调了模拟不同生理状态的必要性. 它讨论了为现实生活条件创建特定患者心血管模型的挑战和机会.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
背景情况:
- 血液动力学对心血管功能至关重要,涉及复杂的机械环境.
- 目前的全身血流模型主要集中在休息,卧状态,忽视现实生活中的生理变异.
- 个体间的变异性和患者特异性建模存在重大挑战.
研究的目的:
- 审查目前在全身血流量建模方面的进展.
- 找出模拟血液流动的机会,超出休息条件,包括运动和睡眠.
- 为了解决针对患者的特定心血管模型的需求.
主要方法:
- 系统规模分布式基于参数的血液流动建模的文献综述.
- 分析模拟非休息的生理状态和个体间变异性的挑战.
- 讨论复杂心血管模拟的方法进步.
主要成果:
- 现有的模型仅限于简化的场景,忽视了关键的生理状态.
- 呼吸,控制机制,重力和器官特异生理学等因素需要进一步调查.
- 患者特异性心血管建模是一个新兴但欠发达的领域.
结论:
- 有必要扩大血液流动建模,以涵盖各种生理状态和患者特定变异.
- 需要先进的建模方法来解决现实生活中心血管动态的复杂性.
- 未来的研究应该专注于开发强大的方法来模拟动态和个性化的心血管功能.
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