对LC-MS的后列和源源衍生工具的仪器仪表和应用进行全面的审查
Nadeem Muhammad1,2,3,4,5, Irshad Hussain5, Xiao-An Fu3
1School of Life Sciences, Wuchang University of Technology, Wuhan, Hubei, China.
Mass spectrometry reviews
|March 13, 2025
概括
本综述侧重于液态染色体质谱学 (LC-MS) 中的后列导化 (PCD). 它强调PCD技术的进步,应用和未来前景,以克服LC-MS挑战.
科学领域:
- 分析化学 分析化学
- 分离科学 分离科学
- 质谱测量质量谱测量
背景情况:
- 液体染色学-质谱学 (LC-MS) 对于分析复杂混合物至关重要,但面临诸如离子抑制和低灵敏度等挑战.
- 现有的线下和在线衍生技术解决了一些局限性,但LC-MS中的后列衍生 (PCD) 仍未得到审查.
- 应对这些挑战对于提高各个领域LC-MS分析的特异性和减少干扰至关重要.
研究的目的:
- 提供对LC-MS最新进展的全面审查,特别关注后列衍生 (PCD) 和源代衍生.
- 批判性地研究PCD在LC-MS中的作用,优点和缺点.
- 探索过去四十年来最新的仪器,方法,影响因素和这些技术的应用.
主要方法:
- 对化学和物理后列衍生物 (PCD) 技术进行审查和批判性评估.
- 对源源内衍生方法的分析.
- 检查仪器仪表的发展和影响LC-PCD-MS的因素.
主要成果:
- 详细概述各种化学和物理PCD技术和源源衍生方法的详细概述.
- 在食品分析,蛋白质组学,生物学,制药和环境科学中探索各种应用.
- 在LC-MS工作流中使用PCD的优缺点的批判性评估.
结论:
- 后列衍生 (PCD) 通过减轻常见的分析挑战,为提高LC-MS性能提供了显著的潜力.
- 进一步开发多功能LC-PCD-MS技术和源代码方法对于解决当前的局限性至关重要.
- 本综述旨在通过提供对LC-MS分析的先进衍生化策略的见解来刺激新的研究途径.
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