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Updated: May 22, 2025

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高性能PBPK模型用于预测CYP3A4诱导介导的药物相互作用:一种精细和验证的方法

Cheng-Guang Yang1, Tao Chen2, Wen-Teng Si3

  • 1Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in pharmacology
|March 13, 2025
PubMed
概括

一个新的生理学基础的药理动力学 (PBPK) 模型准确地预测了由细胞染色体P450酶3A4 (CYP3A4) 诱导引起的药物相互作用 (DDI). 该工具通过可靠预测DDI风险,增强早期药物开发.

关键词:
这是一种CYP3A酶.PBPKK PBPK 的意思是什么意思药物相互作用 药物相互作用药物动力学 药物动力学这种药物是里法皮辛 (rifampicin).

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